Johnny Liu of Game Revolution said that Doctor Nefarious' "psychotic babbling strikes the right balance between threatening and comical". The plot of a upcoming sequel is supposedly to do with rescuing Clank from Nefarious, as referred to by the ending of Quest for Booty. Since Nefarious and Lawrence are still alive, they had a chance to re-appear in a future sequel, and they did return in Quest for Booty by unknown means. In Deadlocked, the two were in range of the Dreadzone Station but failed to transport onto it since it was destroyed. After he is defeated on Mylon, the Biobliterator blows up and leaves Doctor Nefarious and Lawrence stranded on an asteroid awaiting coming in range of a planet or space station (which won't happen for another 5 to ten milleneums). Klunk's true identity is revealed soon after Doctor Nefarious turns all of Metropolis into robots. He spends most of the game on a star cruiser which, when Ratchet, Klunk, and Captain Qwark arrive at, he blows up to try and kill them all. When Clank refused, he built a copy of Clank which he called Klunk to spy on Ratchet and his friends. Dr Nefarious is Secret Agent Clank's biggest fan and captured Clank to try and get him on his side. Courtney Gears appears to have an interest in him, though this is quite evidently not reciprocated. Nefarious himself appears in many cut-scenes, in which he is plotting the downfall of organic life. In a fairly large backstory to the game, Ratchet and the Galactic Rangers fight the Tyrrhanoids across much of the galaxy. In Up Your Arsenal, Nefarious has taken command of the Tyrrhanoid race, and begins with an invasion of Veldin. They are seen there during Ratchet & Clank, while Qwark is acting as the announcer for the hoverboard races. It is also revealed that Nefarious commanded an army of Amoeboids which guard his base on Aquatos and once were sent to attack Blackwater City on Rilgar. Lawrence then knocked Qwark unconscious and took him to another one of Nefarious' bases, from which Qwark soon escaped. Qwark fought Nefarious again on Planet Kerwan, where he was again defeated and had his head thrown in a bin. As Qwark left the base, Nefarious' robotic arm was seen pulling itself out of the wreckage (completely unnoticed by Qwark) the machinery fused with Nefarious. Qwark tried to give Nefarious a wedgie for "old time's sake", which ended up with Nefarious falling into the machinery.
The two flashed back to their biology classes, where Qwark constantly bullied Nefarious. At his base, Qwark encountered Doctor Nefarious on a bridge. According to the Vid-Comic, Qwark saved the city and followed Doctor Nefarious to his base on the molten planet Magmos. Early in his career while still organic, he attempted to kill everyone in Blackwater City on Planet Rilgar with an Amoeboid army. Most of what is known about Doctor Nefarious' past comes from the less-than-reliable Qwark comics featured in Ratchet & Clank: Up Your Arsenal.
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